Hematologics, Inc., a diagnostic service laboratory established in 1995, is built on a long history of research. Its principals and staff, who have decades of training and experience, invented many of the techniques that are now standard in the field:
Over 30 years experience in flow cytometry, starting with the first FACS instrument at Stanford in 1973 [1-3]
Invented multi-color immunofluorescence and multi-angle light scatter [4-6]
Described the antigenic patterns expressed during normal hematopoietic cell development and defined both lineage and maturation of cells in erythroid, myeloid and lymphoid lineages [7-18]
Identified human progenitor cells and the hematopoietic stem cell [19-23]
Developed correction for blood contamination of bone marrow specimens [24]
Developed techniques, including CD45 vs. SSC (right angle light scatter) gating for separation of distinct populations in bone marrow [13, 25-28]
Showed that tumors express normal antigens in abnormal relationships, allowing the detection of residual leukemia based on “difference from normal” [30-33]
Developed and fine tuned techniques for minimal disease detection even in the absence of a diagnostic specimen [34-39]
Advanced the use of flow cytometry for diagnosis and determination of prognostic outcome in MDS [40-46]
Pioneered the use of cell sorting in confirmation of minimal residual disease [39, 46-48]
